The disappearance of Natalee Holloway in 2005 has been seen time and time again on a variety of crime-related television shows.

As recently as this week a cable network aired a program recapping the details of Americaís top 20 unsolved cases. Among the top 10 - the Alabama teenís disappearance in Aruba while on a class trip.

Ironically, Sunday, May 30, marked the five-year anniversary of the 17-year-old Americanís disappearance, it was also the last time anyone saw 21-year-old Stephany Flores Ramirez alive - and guess who she was last seen with.

Joran van der Sloot, the Dutch man twice arrested as a suspect in the disappearance of Natalee Holloway, is now the suspect in the killing of 21-year-old Ramirez, Peruvian police officials said Wednesday.

Ramirez was found slain in a Lima hotel room Wednesday.

There is "incriminating evidence" linking Van der Sloot to the killing of Ramirez, Cesar Guardia Vasquez, of the criminal investigations unit said at a news conference.

The hotel room where Flores was found was registered in Van der Sloot's name, he said.

A hotel guest and an employee witnessed the pair entering the hotel room together at 5 a.m. on Sunday, Guardia said.

Police have video of the previous night, May 29, of Van de Sloot and Flores together at the Atlantic City Casino in Lima, he said.

According to immigration officials, Van de Sloot fled to Chile over land on Monday, Guardia said.